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We hypothesized that characterization of patients' metabolic profiles, utilizing high resolution 1H-nuclear magnetic resonance (NMR) may predict response to therapy prior to treatment

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The researchers showed that FOXO4-DRI treatment induced apoptosis specifically in senescent chondrocytes while sparing healthy proliferating cells, confirming the selectivity mechanism described in the original Baar et al

Methionine-R-sulfoxide reductase B1 (formerly selenoprotein R) The methionine sulfoxide reduction system is involved in the protection against oxidative stress and is especially critical for the regeneration of proteins damaged by ROS