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A systematic review found no clinical safety data beyond a very small case series, emphasizing that the safety profile for chronic use in humans remains uncharacterized

10.1016/j.vph.2018.02.010 147 VukojevicJ.VrdoljakB.MalekinusicD.SiroglavicM.MilavicM.KolencD.et al (2020)

They have been handled, shipped, and stored in non-sterile environments

Mechanosensation and mechanotransduction Mechanical sensors on endothelial cells detect shear stress and convert it into biochemical signals to trigger vascular adaptive response

The plunger may push back upwards several times before you are finished

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