For custom combination protocols where GHK-Cu is dosed alongside other compounds in separate vials, the GHK-Cu dosing is calculated independently and administered on its own schedule
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This isn't just about protecting yourself
This fundamental characteristic makes a true vitamin B12 overdose exceptionally rare in clinical practice
First, the effect is enzymatic and cumulative you are shifting a metabolic set-point over days and weeks, not triggering an acute hormonal event, which is why steady daily exposure matters more than any single large dose
Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)
