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In addition, both riboflavin and PLP are essential determinants of the kynurenine pathway which influence glutamate receptors, hence, glutamate excitotoxicity potential, as shown in Section Riboflavin as a Determinant of the Kynurenine Pathway. Concerning PD, glutamate excitotoxicity contributes to dopaminergic neuronal loss (84)

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Importantly, apoptosis and necroptosis of nucleated cells have opposite immunogenic effects (anti-inflammatory and pro-inflammatory, respectively) [247]

Patient experiences with prolotherapy are mixed but often positive