trisomy glutathione Altered Ca2+ Signaling and Mitochondrial Deficiencies in Hippocampal Neurons of 16 Mice: A Model of Down's Syndrome Oxidative stress biomarkers as novel

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Consistent with its disruptions of mitochondrial respiration reflected in the cells OCR measurements, CB-839, starting at low concentrations of 0.1 to 1 M, also decreased the ATP pool in the HG-3 (P = 0.02) and MEC-1 (P = 0.01) cell lines, as measured using high-performance liquid chromatography ( Figure 2D ).The levels of other nucleotides remained stable at all concentration points

Reaction mechanism of glutathione synthetase from Arabidopsis thaliana : site-directed mutagenesis of active site residues