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In 2016, concerns regarding retinopathy associated with GLP-1 were first raised in the Semaglutide Unabated Sustainability in Treatment of T2DM (SUSTAIN) 6 trial with semaglutide [89]

Common signs include tiredness, memory issues, pale skin, mood changes, and tingling in the hands or feet

For some, immune overactivation or gut imbalances are key contributors

It has attracted growing interest in experimental research investigating the role of NNMT (Nicotinamide N-methyltransferase) inhibition, a pathway linked to metabolic activity and cellular energy balance

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