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Summary: Alpha-lipoic acid does not appear to be beneficial for progressive multiple sclerosis based on the most rigorous clinical trial available, and it was associated with more adverse effects including kidney-related concerns

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[6] [7] [8] Complex I deficiency with recessive spastic paraparesis has also been linked to MTHFR variants

TB-500 (synthetic TB4) has been clinically tested for its wound healing potential, with the following two studies worth noting: In a randomized, double-blind, placebo-controlled study with dose escalation, patients suffering from venous stasis ulcers were administered synthetic TB4 locally over a period of 84 days

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