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Cells are provided with efficient molecular strategies to strictly control the intracellular ROS level and to maintain the balance between oxidant and antioxidant molecules

[107] also found that anti-MDA antibodies have a role in accelerating bone erosion in RA via inducing glycolysis and lipid biosynthesis of osteoclasts

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This effect was not restricted to Venetoclax, as knockout or pharmacologic inhibition of ABCC1 also sensitized AML cells to other BH3 mimetics, including ABT-737, Navitoclax and the novel BCL-2/BCL-xL inhibitor AZD-4320

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