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Dual Inhibition of MDM2 and XPO1 Induces Synergistic Apoptosis in Wild-type p53 Acute Myeloid Leukemia through Nuclear Accumulation of p53 and Suppression of c-Myc

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By 1993, Yoshiko Sonoda successfully purified the human CYP51A1 protein from liver microsomes and demonstrated its catalytic activity upon reconstitution with NADPH cytochrome P450 reductase (3.20 mmol per mg of protein /min), identifying its molecular weight as approximately 53 kDa [12]

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