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It is possible that compensatory mechanisms could develop that reduce efficacy with prolonged use

(2013) 'Vitamin C for preventing and treating the common cold', Cochrane Database of Systematic Reviews, Issue 1

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In LC-MS/MS workflows, mass detection can improve selectivity when the method is suitable for the analyte and matrix [13]

Interestingly, evidence suggests that LL-37 and A 142 may in fact be natural binding partners that would be significant to the spatiotemporal ratios of the two peptides under disease conditions (De Lorenzi et al., 2017)