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Second, the respective study populations were quite different, with STEP 1 including a younger, healthier population with more women (73.1% of the semaglutide arm in STEP 1 versus 27.7% in SELECT) and higher mean BMI (37.8 kg m 2 versus 33.3 kg m 2 , respectively) 14,21

Numerous studies point to oxidative stress as a possible explanation for a number of DS-related problems, such as intellectual disability, accelerated aging, and cognitive and neuronal dysfunction [14, 19, 20, 21]

Headache: Occasional, usually during the first week as the body adjusts to increased GH pulsatility