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Over long durations, a higher concentration of hormones may be required to overcome physiological ancillary impacts

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Conclusions Results of this study indicated that, in contrast to livestock mammals and poultry where creatine synthesis requires the interorgan cooperation of the kidneys and liver but is absent from skeletal muscle, creatine synthesis occurred primarily in skeletal muscles from Phase-I and Phase-II HSB

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Hepatology 2003, 38:692702