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In an inflammatory setting induced by IL-1, increased levels of hypoxia-inducible factor-2 (HIF-2) coupled with diminished GPX4 expression in chondrocytes increase their susceptibility to ferroptosis ( Figure 4 ) (80, 161)
These play a significant role in neurotransmitter production, inflammation control and barrier regulation and their depletion is frequently observed in individuals with depression and anxiety further suggesting their relevance to mental health (Xiong R.-G
The hexapeptide structure of dihexa makes it vulnerable to proteolytic enzymes in the gastric and hepatic environment, meaning oral bioavailability rarely exceeds 1520% even under ideal conditions
What it means for you: Offering this as a standard post-procedure add-on differentiates your aftercare protocol and gives clients a reason to book their next procedure with you specifically, knowing recovery will be better managed
Apply gentle pressure with a clean cotton or alcohol pad