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Phase 1: Introduction (weeks 1 to 4) Start below your expected long-term concentration

Localization of IL-12 to the angiogenic vasculature significantly enhanced the antiangiogenic effect in corneal angiogenesis assay, augmented antitumor activity in a neuroblastoma model, and decreased toxicity of the IL-12

In fact, the vascular endothelium grows in the body as a monolayer of cells lining the inner surface of blood vessels within a 3D microenvironment supported by collagen and proteoglycan ECM [241, 242]

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[DOI] [Google Scholar] 12.Bjrklund G., Peana M., Maes M., Dadar M., Severin B