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In Vitro

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In macrophages with the M1-like phenotype, arginine is converted into nitric oxide (NO) and citrulline via inducible nitric oxide synthase (iNOS), and this anabolic pathway is closely associated with macrophage cytotoxicity and antitumor effects

In hyperlipidemia-associated hepatic steatosis, GLPs exert potent hypolipidemic effectsmarkedly lowering serum TC, TG, and LDL-C, while elevating HDL-Cthereby mitigating lipid accumulation and structural damage in hepatocytes

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Methionine intake, folate levels, and vitamin B12 availability all influence the cycle's capacity to support methylation and homocysteine clearance