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Extracellular signals are mainly mediated by Wnt proteins, including Wnt3a, Wnt1, and Wnt5a
GSH is synthesized de novo in the brain by astrocytes and research has demonstrated increased GSH synthesis during oxidative stress-related toxicity in vitro , proposing in vivo synthesis of this antioxidant might be sufficient to not detect significant changes (14)
It's biochemically inactive, converting an expensive research compound into sterile water
J Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R (2018) The gut-liver axis and the intersection with the microbiome
Figure 1 Cancer is a major social, public health, and economic issue of the 21st century, accounting for almost one in six (16.8%) deaths worldwide and one in four (22.8%) deaths from non-communicable diseases
If you cant protect the upside, its tough to justify a $20100M clinical program
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