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In addition to being directly activated by NAPQI, protein tyrosine phosphatase 1 B (PTP1B), 42 fibroblast growth factor 21 (FGF21), 43 and the M1 muscarinic receptor (M1R) 44 have also been found to modulate the Nrf2 signaling pathway

Each drugs have its own mechanism of action, such as antimonials are believed to interfere with the parasites energy production, inhibiting glycolysis and fatty acid oxidation

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Niacinamide , which is another ingredient known to stop melanin production in the skin