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Instead, glutaredoxins are reduced by the oxidation of glutathione

GPX4 (glutathione peroxidase 4) and Quercetin GPX4 is highly expressed in tubular epithelial cells and its level is a predictor for renal outcomes, ferroptosis (antioxidant role in lipid peroxidation), and patients with diabetic kidney disease (DKD) are associated with (Wang, Chang, Zhao, & Chen, 2022) where increased urinary protein, serum creatinine, estimated glomerular filtration rate, and the percentage of sclerosed glomeruli in renal specimens

USA 102 , 23102315 (2005)

An insoluble polysaccharide from the sclerotium of poria cocos improves hyperglycemia, hyperlipidemia and hepatic steatosis in ob/ob mice via modulation of gut microbiota

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however, excessive intake counteracts these potential benefits [246]