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Our findings are in agreement with other recent observations using similar ligature models, which show a considerable increase of the distance between the cemento-enamel junction and the alveolar crest, regarded as a sign of alveolar bone loss (48, 52)

These results indicated that mesenchymal progenitor like and pro-inflammatory fibroblasts were involved in keloids senescence which may play crucial roles in the aggression and recurrence of keloids

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That distinction carries three practical caveats worth stating plainly: Dose translation is not one-to-one