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255 Similarly, Sandalwood seed oil has been shown to improve insulin resistance in rats induced by a high fat/high sugar diet, with mechanisms related to changes in gut microbiota composition and the production of microbial metabolites (including TMAO)

Supporting this concept, total glutathione concentration appears to declines with aging, as demonstrated in both rat models of aging and in human aging (particularly after age 45 in humans), possibly due to a reduced ability to synthesize GSH

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