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Endocr Rev 26:944984

In the USA, in 2022, 1 in 6 deaths (17.5%) from cardiovascular disease was due to stroke

In general, disordered domains are unsuitable targets for potent peptide binding because of the lack of well-defined binding surfaces, conformational flexibility, and associated entropic penalties 60,61

B., Jang, Y

So one of the strongest arguments in this thesis is also one of the easiest to overstate: the field has matured procedurally, but the human clinical record is still substantially more developed for some substances than others