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Possible long-term risks of vitamin B12 Most side effects of high doses of B12 are rare and temporary

Based on the data available in 2015, EFSA did not identify any known health risks associated with the use of dietary supplements, so no maximum dose or maximum daily intake, also known as a tolerable upper intake, was set (EFSA, 2015)

Its best to avoid alcohol while using ibuprofen frequently

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Dermatological reactions represent the most consistently documented side effect of excessive B12 intake

& Goebel, W