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The trial enrolled 809 adults with obesity and at least one comorbidity, with a mean baseline body weight of 114.2 kg

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These findings support the notion that, similar to the development of peripheral opioid receptor antagonists, developing therapeutic targeting specific brain regions is one of several avenues that warrant exploration for patients unresponsive to current therapies

Adjust dose and timing to previous cycle trends and lab markers such as thyroid and antiphospholipid antibodies