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Expression of Cyp7a1, the rate-limiting enzyme of BA synthesis, was significantly increased by re-feeding similarly in WT/ND mice and Insr P1195L/ +/ND mice, while that in WT/HFD mice was significantly elevated under fasted condition and did not show further increase by re-feeding

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(PubMed) Chapman LE, Darling AL, Brown JE

The studies summarized below are preclinical and should be interpreted accordingly

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