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This oxidative insult has been demonstrated to impair pancreatic -cell function and exacerbate insulin resistance, thereby contributing to the progression of T2DM [310]

This suggests that lower circulating 25(OH)VD levels could be a result of the decreased VDBP levels seen in obese adolescents

It is known that ionizing radiation induces oxygen radical injury, whereas oxidative stress by the radiation can cause cellular responses to defense cellular injury

Antioxidants & Redox Signaling, 18 (13), 16421653

Free Radic Biol Med 36, 288299.Google Scholar Yang, NC, Lin, HC, Wu, JH et al