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Symptoms include: Persistent fatigue and lack of motivation Decreased libido or erectile dysfunction Loss of muscle mass and strength Weight gain and slower metabolism Mood changes, irritability, and poor focus Reduced bone density A meta-analysis published in Clinical Endocrinology confirmed that TRT significantly increases lean body mass and decreases fat mass in hypogonadal men (Corona et al., 2016)

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Men who cannot tolerate the gastrointestinal effects of semaglutide or tirzepatide may find cagrilintide more manageable as a standalone option

doi: 10.1016/s1570-0232(02)00273-8