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Although many enzymes in one-carbon metabolism are affected by the sex hormones testosterone and estradiol, the main reasons for sexual dimorphism in glutathione metabolism are the effects of estradiol and the GSH regulatory motif, which includes the inhibition of GS and GCL by GSH itself [Figure 2B]

Firstly, the issue of causal strength arises

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However, owing to the narrow therapeutic window, NAC needs to be used within 8 h after APAP poisoning to achieve good therapeutic efficacy

(2012a)

Whey protein can increase intracellular glutathione by up to 64% while providing protection against oxidative stress