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Vitamin B12, or cobalamin, is a fundamental nutrient required for DNA synthesis, red blood cell formation, and neurological health

The proposed chain of effects looks like this: NNMT inhibited nicotinamide is no longer inactivated by methylation and becomes available for conversion to NAD+

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At a glance: RDA: 2.4 mcg/day (adults) UL: Not established (insufficient evidence to set a tolerable upper limit) [ref] Dietary considerations: Vegan and vegetarian diets: Vitamin B12 is only found in animal-based foods, so vegans and vegetarians are often deficient or marginal in their B12 status.[ref] B12 is often added to breakfast cereals and other refined products, so eating a vegetarian diet that includes packaged and refined foods may actually result in higher B12 levels (although probably not in better health)

"Oral Vitamin B12 Supplementation After Roux-en-Y Gastric Bypass: a Systematic Review"