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J Am Pharm Assoc (Wash) 41 , 437447 (2001)

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However, in these acne studies, CBDs effects have only been tested on the skin

Heres how they compare to alternatives: Oral Glutathione Supplements Effectiveness: Much lower than IV (only 10-20% absorption rate vs 100% for IV) Cost: Rs.3,000-8,000 per month Results Timeline: Requires 3-6 months of daily use for visible brightening Best For: Maintenance after IV course, budget-conscious options, those who dislike needles Topical Brightening Treatments Options: Vitamin C serums, niacinamide, kojic acid, alpha arbutin, retinol Effectiveness: Works only on surface layer

That last point is an inference from how the procedure works and what it is used for

82 The promising mechanism of action of TLK286 and its positive preclinical data have sparked a series of clinical trials where the prodrugs have been applied alone or in combination with other standard chemotherapeutic agents