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The situation changed in the late 1980s with the advent of the so-called soft ionization techniques of electrospray ionization (ESI) (Fenn et al., 1989) and matrix-assisted laser desorption/ionization (MALDI) (Clarke, 2019)

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So there is a little bit of concern about that. Its a concern that has been pervasive enough for existing drugs that Lilly released a commercial ahead of the 2024 Oscars urging against vanity use