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Consistently high GGT levels are strongly linked to a higher risk of several age-related diseases: Cardiovascular Disease: Oxidative stress is a key player in the inflammation and damage that occurs in our blood vessel walls, which can lead to heart attacks and strokes
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The latter is a competitor of 2-Oxoglutarate-dependent dioxygenases such as Ten-eleven translocation methylcytosine dioxygenase and therefore induces DNA hydroxymethylation and gene upregulation 52