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They actively supinate against the examiners resistance Differential Diagnoses The main differential diagnoses* to consider in a patient with suspected biceps tendinopathy include inflammatory arthropathy, radiculopathy, osteoarthritis, or rotator cuff disease (for proximal tendon involvement) *Biceps tendinopathy is rarely an isolated pathology and often the differentials may be co-existing, hence the need for thorough history and examination Investigations The diagnosis of bicep tendinopathy is largely clinical , with further investigations reserved for cases where there is diagnostic uncertainty