Eight weeks of aerobic exercise significantly activated the System Xc /GPx4 signaling pathway in the prefrontal cortex of APPswe/PS1dE9 transgenic AD mice, up-regulated FTL and BACE1 expression, significantly downregulated 4-HNE levels, inhibited oxidative stress, lipid peroxidation, and ferroptosis, reduced A positivity, alleviated neuronal morphological abnormalities, and improved learning and memory functions in AD mice (Li et al., 2024a)
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G6PD-d has the powerful potential to yield both atheroprotective and proatherogenic outcomes through its effects on cell survival, proliferation, activation, and cellular signaling in RBCs, VECs, VSMCs and different immune cell subsets
In parallel experiments, whole brains from two rats were rapidly removed and placed in ice-cold isolation buffer
Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression
Monitoring and consultation with healthcare providers are recommended
