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10.1016/j.ccell.2018.03.004 125 ToumiR.SamerA.SoufliI.RafaH.Touil-BoukoffaC

The connection likely relates to epitalon's effects on pineal function and circadian regulation, both of which become disrupted during the menopausal transition

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These microbiota-derived agents can inhibit Gram-negative pathogens through diverse mechanisms, such as direct bactericidal activity, modulation of host immune responses, and promotion of colonization resistance

Its progressive dysfunction with agedecline in NAD+, accumulation of ROS, reduction in mitochondrial biogenesisis a central mechanism of aging and degenerative diseases

[DOI] [PubMed] [Google Scholar] 119.Hilchie A, Hoskin D, Power Coombs M