Downstream genes regulated by the Nrf2/ARE axis include HO-1, NQO1, and iron metabolism-related proteins (FTH1, FTL, FPN1), etc.: HO-1 degrades pro-oxidative heme to produce bilirubin with iron-chelating activity, and NQO1 directly scavenges lipid free radicals
It also includes powerful cofactors like ALA and L-Cysteine to support bioavailability and help Glutathione function optimally
Alp NJ, McAteer MA, Khoo J, Choudhury RP, Channon KM
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A casecontrol study of 84 screen-detected children with CD and 443 healthy controls found significantly lower serum levels of hemoglobin, iron, ferritin, vitamin D, zinc, copper, and selenium in the celiac group, with more severe intestinal lesions associated with reduced ferritin and vitamin A (96)
Unlike other antioxidants you consume (vitamin C, E), glutathione must be produced inside your cells from three amino acids: cysteine, glycine, and glutamate