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SECOND OPINION SERIES Natural Treatment for OCD Symptoms: Glutamate, NMDAR, Diet and Biochemical Patterns A natural treatment for OCD symptoms should look beyond serotonin alone and ask whether glutamate overload, NMDA receptor overactivity, undermethylation, copper-zinc imbalance, histamine reactivity, oxidative stress, toxic burden, or mitochondrial strain is driving the intrusive thought loop