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Antigen presentation by DCs activates CD8 + T cells, which migrate to lesion sites and destroy melanocytes by secreting IFN-, perforin, and granzyme B

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Its main characteristics are as follows (1): During the process of cell death, a large amount of iron accumulates, and lipid peroxidation occurs, activating signaling pathways such as oxidative stress ( Table 1 Comparison of cell death pathways

Estudios genticos han identificado numerosos loci asociados con el vitligo, destacando la participacin de genes relacionados con la inmunidad adaptativa e innata, as como con el metabolismo celular

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