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Since the mean/median duration for each of these studies was 100,000 patients prescribed a GLP-1RA, after propensity matching, there was reduced risk for PDAC during a 5-year observation period for GLP-1RA users compared to six categories of commonly used diabetes medication classes 44

Ipamorelin mimics ghrelin and stimulates GH release with no significant increase in ACTH or cortisol (Raun et al., European Journal of Endocrinology )

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Buckman TD, Kling AS, Eiduson S, Sutphin MS, Steinberg A

The main interface between the general circulation of the body and the CNS-compartment is the BBB

A subset of cultured cells expressed GLP- 1 receptor, and mice with a-cell specific GLP- 1 receptor knockout have mild glucose intolerance and higher glucagon secretion in response to glucose challenges than animals of the wild type, which may indicate that GLP- 1 directly affects this cell [69]