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10.1016/j.intimp.2023.110593 115 MarkoulliM.AhmadS.ArcotJ.AritaR.Benitez-Del-CastilloJ.CafferyB.et al (2023)

In some embodiments, the otic formulation or composition comprises about 4% by weight of the silicon dioxide

Ghosh D, Porter E, Shen B, Lee SK, Wilk D, Drazba J, Yadav SP, Crabb JW, Ganz T, Bevins CL: Paneth cell trypsin is the processing enzyme for human defensin-5

1169 (60%) had cerebral infarction, 296 (15%) haemorrhagic stroke, 106 (5%) TIA and 379 (20%) stroke mimics

These data suggest a benign safety profile in animal models

There have also been reports of non-insulinotropic effects of GLP- 1 receptor activation