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By keeping realistic expectations and taking a thoughtful, evidence-informed approach, it is possible to work gradually toward healthier-looking and more even-toned skin over time

Acknowledgments This work was supported by the competitive funding of Pirkanmaa hospital district (9E112 and 9D099) to R

These include methyl donors (such as DMG, TMG, betaine), fatty acids to help reduce inflammation (such as fish oil, flax seed), minerals (such as zinc, magnesium), herbs that support liver detoxification (such as milk thistle), vitamin C, and amino acids

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[11] Use is not recommended in those who are allergic to cobalt or have Leber's disease