One more LCD note: corticosteroids arent FDA-approved for epidural injection, per the FDAs 2014 epidural corticosteroid safety communication
This may be due to copper's ability to enhance the expression of metalloproteinases (MMPs).16 MMPs normally regulate the degradation of collagen, and a specific one, MMP-1, may be responsible for the initiation of collagen fragmentation.17 Supporting this, a 2024 study noted that elevated MMP-1 levels appear to contribute to aging skin and that higher MMP-1 levels in mice led to:18 The loss and fragmentation of dermal collagen fibrils Contracted fibroblast morphology Reduced collagen production Increased expression of pro-inflammatory mediators Additionally, a 2016 study found that GHK-Cu significantly increased gene expression of MMP-1 and MMP-2 at the lowest concentration, which the studys authors considered to be one of the reasons the peptide was able to increase collagen and elastin production.19 So, what this could ultimately mean is that using too much GHK-Cu (or other copper peptides) may in theory increase the skins MMP-1 concentration above the levels involved in healthy collagen production, taking it into the collagen fragmentation and breakdown territory seen in older skin with naturally higher MMP-1 levels
Additionally, because injections bypass the digestive system, they are not subject to the exact breakdown and loss of potency that can occur during digestion
Step-by-Step: How to Give a Vitamin B12 Shot (IM Method) Step 1: Wash and Sanitize Wash your hands thoroughly with soap and water
How long do B12 injections take to work
