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However, numerous studies indicate that individuals with ME/CFS experience increased intestinal permeability, supporting the theory that Gram-negative bacterial endotoxins, also known as LPS, may enter the mesenteric lymph nodes and the blood stream through the loosening of tight-junction proteins (e.g., Zonulin), triggering an immune response and resulting in systemic inflammation [10, 21, 24, 39,40,41,42]

Please note that using protein interactions as a selection criterion alone would yield 84 targets (Supplementary Data 5)

A thoughtfully formulated peptide supplement that blends naturally acetylated and amidated forms of BPC-157, KPV, and Immune Peptide A2 with a robust combination of probiotics and prebiotics, including Akkermansia, Lactospore, and Fructo-oligosaccharides

1998 Nov-Dec;18(6A):4383-6

PMID: 67 BadalVDVaccarielloEDMurrayERYuKEKnightRJesteDVet al