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We found that tamoxifen at concentrations, which accumulate in tumors during therapy, increases oxidative stress in ER-positive and ER-negative breast cancer cells, resulting in cell death

The reasons: Receptor sensitivity: While GHK-Cu doesn't appear to cause receptor downregulation the way some peptides do, cycling is a general precaution to maintain responsiveness and avoid adaptations that might blunt benefits

doi: 10.1016/j.addr.2021.05.008 157 RogalJSchlnderKLoskillP

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Stability and storage considerations that recur across the research-peptide literature include: It bears repeating that meticulous handling changes nothing about the evidence question