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For many individuals, oral B12 supplements are ineffective due to such underlying conditions as: Pernicious anemia : People with this condition lack intrinsic factor, a protein required for B12 absorption in the small intestine

Amyloid- is known to bind catalase with high affinity, which in turn inhibits the breakdown of hydrogen peroxide (Milton 1999)

Adequate levels of selenium were observed in 24/36 (66.7%) in this evaluated population

Investigating the Role of Iron-Sulfur Signaling in Yeast Transcriptional Regulation

H., Handelsman, Y., Insel, R

Research suggests that those with autoimmune diseases lack optimal antioxidant function