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Realistically, fundamental issues that stand in the way of large-scale drug production include the vast number of biological GST family members, with each subtype having their own structural and functional differences, in addition to the existence of several genetic modifiers

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aeruginosa , the MexR repressor senses oxidative stress (two Cys residues form disulfides), dissociates from the mexAB-oprM promoter, and derepresses efflux under peroxide stress