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104 Subsequent degradation of TJs results in the release of cytokines, including interleukin-1 (IL-1), tumor necrosis factor (TNF), and MMPs

GHK-Cu downregulates acute-phase and pro-inflammatory cytokines (TNF-?, IL-6), upregulates anti-oxidant defenses (including superoxide dismutase, Nrf2 and HO-1 pathways), and suppresses fibrotic signaling by inhibiting TGF-?1/Smad2/3 activation

Wichmann T, Delong M

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The complexity of the ERK/MAP-kinase pathway and the treatment of melanoma skin cancer