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Dehydration can have a direct impact on this function
Guo M, Hao Y, Feng Y, Li H, Mao Y, Dong Q, et al
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Although ZEA raised the MDA content and the creatinine, urate, and blood urea nitrogen levels in mouse kidneys while lowering GSH-Px and T-SOD activity, Se mitigated these changes, causing the kidneys to recover from renal damage (138)
Nrf2 is an important transcription factor involved in iron metabolism and oxidative stress in the brain