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pylori virulence factors (Urease, NAP, VacA and CagA)
Kross and Scheer, 1991), and the ClO 2 prodrug NaClO 2 has also been approved as an ALS orphan drug by the European medicines agency (EMA) (EU/3/13/1139, 2024), and has demonstrated efficacy in a subset of ALS patients administered NaClO 2 intravenously in a Phase 2B clinical trial, notably reducing LPS levels in the blood which would suggest antimicrobial efficacy (Zhang et al., 2022)
153 The extracellular matrix (ECM), a non-cellular component of the tumor microenvironment, has a physical structure and chemical composition often associated with tumor progression
An increasing number of studies have highlighted that the dysregulation of metabolites, such as amino acids and lipids, including arachidonic acid (AA) and bile acid metabolism, are also implicated in renal fibrosis [28-31]
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