In heterozygotes, mutated chains interfere with the assembly of anchoring fibrils by normal type VII collagen chains
This is due to biotin sharing its transporter with vitamin B5, so theoretically taking high doses of one could impair uptake of the other
The findings cited above are taken from preclinical, animal-model, and in vitro studies and are reported here for research context only
The methylcobalamin component does not change this calculus
Directly, the copper coordination prevents free copper-catalyzed Fenton reactions that generate hydroxyl radicals, while the peptide sequence itself can scavenge existing reactive oxygen species
Beyond commercial feasibility, manufacturing-derived impurities can independently provoke adverse immune responses