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Previous studies showed that a uric acid dose of 5 mg/dl significantly increased superoxide anion accumulation at 1 h in primary rat VSMCs (47)

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Therefore, we speculated that DMF could affect 2OG or 2HG levels to affect DNA methylation and revisited the initial LC-MS analyses which showed there are significantly reduced levels of 2HG, but not 2OG after DMF treatment (Fig

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